Dominique Toppani

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Dominique Toppani has made foundational contributions to structural genomics, particularly in the automation of protein crystallization and structure determination. As a key figure in the TB Structural Genomics Consortium—one of nine NIH-sponsored P50 centers—Toppani spearheaded the development of a high-throughput crystallization facility that streamlined the entire pipeline from protein production to electron density maps. Their most cited work, "The TB structural genomics consortium crystallization facility: towards automation from protein to electron density" (2002, 52 citations), introduced automated crystallization, data collection, and bias-minimized molecular replacement solutions, dramatically accelerating structural studies of tuberculosis proteins. This work laid critical groundwork for laboratory-scale structural genomics, as detailed in their 2004 paper (19 citations), demonstrating how small, focused teams could implement automated workflows previously reserved for large consortia. Toppani's contributions bridged the gap between high-throughput structural biology and practical laboratory implementation, enabling more efficient target selection and structure solution. Their achievements underscore the importance of automation in modern structural biology, making protein structure determination more accessible and reproducible for researchers worldwide.