Brent W. Segelke

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About

Brent W. Segelke is a structural biologist whose work has significantly advanced the field of structural genomics, particularly in the context of tuberculosis (TB) research. His primary contributions lie in the development of high-throughput crystallization and structure determination pipelines, which have been instrumental in accelerating the discovery of protein structures. Segelke’s most notable work, “The TB structural genomics consortium crystallization facility: towards automation from protein to electron density” (2002), with 52 citations, details the automated systems he helped pioneer for the TB Structural Genomics Consortium. This facility streamlined the entire process—from protein crystallization to data collection and molecular replacement—enabling rapid, bias-minimized structure solutions. His follow-up work, “Laboratory scale structural genomics” (2004, 19 citations), further refined these methods for smaller labs, democratizing access to structural genomics tools. Segelke’s impact is evident in how his automation strategies have become foundational for modern structural biology, reducing bottlenecks in drug target identification. His achievements underscore a career dedicated to merging technology and biology, making him a key figure in the fight against TB through structural insights.