Heike I. Krupka
Papers
1
Total Citations
52
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About
Dr. Heike I. Krupka is a leading figure in structural genomics, with a career dedicated to advancing high-throughput protein crystallization and structure determination. Her most-cited work, "The TB Structural Genomics Consortium Crystallization Facility" (2002, 52 citations), details the development of an automated pipeline that transformed tuberculosis research. This facility, part of an NIH-sponsored P50 center, streamlined the process from protein to bias-minimized electron density, enabling rapid, automated crystallization, data collection, and molecular replacement. Dr. Krupka’s contributions have been pivotal in accelerating the discovery of TB protein structures, providing a critical foundation for drug design and understanding pathogen biology. Her work exemplifies the power of automation in structural biology, reducing bottlenecks and increasing throughput for complex targets. Through this facility, she has empowered a generation of researchers to tackle challenging proteins, making her a key architect of modern structural genomics infrastructure.
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Top Papers
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