Matthew A. Coleman

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About

Matthew A. Coleman is a structural biologist whose work has helped bridge the gap between genomic data and three-dimensional protein structures. His research focuses on high-throughput structural genomics, developing methods to rapidly determine protein folds and functions on a laboratory scale. Coleman’s most cited work, "Laboratory scale structural genomics" (2004, 19 citations), outlines a systematic pipeline for cloning, expression, purification, and crystallization of target proteins—a foundational approach that has enabled cost-effective, small-scale structural determination. This contribution has been instrumental for researchers seeking to characterize proteins from newly sequenced genomes without the resources of large consortia. By demonstrating that structural genomics can be performed efficiently in a single lab, Coleman has empowered smaller groups to tackle challenging biological questions. His work underscores the importance of methodological innovation in accelerating the pace of discovery, and his pipeline remains a reference point for those entering the field of structural biology.