Constantinos Kousoulos
Papers
10
Total Citations
259
H-Index
9
About
Constantinos Kousoulos is a prominent analytical chemist whose research has made significant contributions to the field of bioanalytical method development, particularly in the quantification of pharmaceutical compounds in human biological matrices. His work centers on developing and validating high-throughput liquid chromatography/tandem mass spectrometry (LC-MS/MS) methods, with a strong emphasis on automation and efficiency in clinical and bioequivalence studies. Kousoulos has been instrumental in advancing sample preparation techniques, pioneering the use of automated 96-well format plate systems for liquid-liquid and solid-phase extraction, dramatically improving laboratory throughput without sacrificing analytical precision. His validated methods span a diverse range of clinically important drugs, including donepezil, itraconazole, simvastatin, risperidone, terbinafine, and anastrozole, reflecting the broad applicability of his innovations across therapeutic categories. With cumulative citations exceeding 250 across his most recognized publications, his work has been widely adopted by researchers conducting bioequivalence and pharmacokinetic studies worldwide. His most cited paper on donepezil quantification (46 citations) exemplifies his hallmark approach: combining automation, sensitivity, and rigorous validation. Kousoulos's contributions have meaningfully streamlined pharmaceutical analysis, supporting faster and more reliable drug development workflows.
Research Focus
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