Constantinos Apostolou
Papers
9
Total Citations
227
H-Index
8
About
Constantinos Apostolou is a prominent analytical chemist whose research has profoundly advanced bioanalytical methodology, particularly in the development of high-throughput quantification techniques for pharmaceutical compounds in human plasma. His work centers on liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS), with a specialization in automating and optimizing sample preparation workflows using 96-well format plate technology. Apostolou has made significant contributions to the bioequivalence and pharmacokinetic fields by developing rigorously validated methods for quantifying a diverse range of clinically important drugs, including donepezil, itraconazole, simvastatin, terbinafine, anastrozole, and pantoprazole, among others. His most cited work, on donepezil determination (46 citations) and itraconazole analysis (44 citations), exemplifies his ability to translate automation into practical, reliable analytical solutions. By championing automated liquid-liquid and solid-phase extraction techniques, Apostolou has consistently reduced analytical turnaround times while maintaining stringent accuracy and precision standards. Collectively accumulating over 220 citations, his body of work has become a valuable reference for researchers and pharmaceutical scientists seeking efficient, reproducible bioanalytical strategies in clinical and regulatory settings.
Research Focus
Key Achievements
Top Papers
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