Georgios-Stefanos Soumelas

About

Georgios-Stefanos Soumelas is a bioanalytical chemist whose work has advanced the quantification of drugs in biological matrices, with a focus on bioequivalence studies. His research centers on developing highly sensitive and automated LC-MS/MS and HPLC methods for therapeutic monitoring. A key contribution is his fully validated LC-MS/MS method for the simultaneous quantification of simvastatin and its active metabolite, simvastatin acid, in human plasma—a technique that has garnered 42 citations for its robustness in pharmacokinetic studies. He also pioneered a semi-automated 96-well format solid-phase extraction protocol for alendronate determination in urine, cited 24 times for its efficiency in bioequivalence trials. Notably, his work on cilazapril and cilazaprilat introduced complete automation using robotic liquid handling and 2.2 mL deep-well plates, achieving high throughput with minimal manual intervention. These innovations underscore his impact on streamlining sample preparation and analysis, reducing error, and accelerating drug development. Soumelas’s methods remain foundational for researchers seeking reliable, high-throughput bioanalytical solutions.

Research Focus

Key Achievements

Top Papers

1. 1
   An improved and fully validated LC–MS/MS method for the simultaneous quantification of simvastatin and simvastatin acid in human plasma

   42 citations · 2007
2. 2
   Application of a semi-automated 96-well format solid-phase extraction, column-switching, fluorescence detection protocol for the determination of alendronate in human urine samples obtained from a bioequivalence study

   24 citations · 2006
3. 3
   Advantages of Automation in Plasma Sample Preparation Prior to HPLC/MS/MS Quantification: Application to the Determination of Cilazapril and Cilazaprilat in a Bioequivalence Study

   4 citations · 2011

Key Collaborators

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