Akeo Shinkai
Papers
1
Total Citations
29
H-Index
1
About
Dr. Akeo Shinkai has made foundational contributions to structural genomics, with a particular focus on the thermophilic bacterium *Thermus thermophilus* HB8. His work centers on high-throughput protein crystallization, a critical bottleneck in determining protein structures. In his most cited study, he developed and validated a comprehensive crystallization screening pipeline by integrating three robotic systems: the HTS-80 for sitting-drop vapor diffusion, the Crystal Finder for hanging-drop vapor diffusion, and the TERA for modified microbatch methods. This multi-robot approach dramatically increased the efficiency and success rate of crystallizing diverse proteins from *T. thermophilus*, enabling the large-scale structural determination efforts of the whole-cell project. With 29 citations, this work has served as a methodological cornerstone for subsequent structural genomics initiatives. Dr. Shinkai's contributions have not only advanced our understanding of thermophilic protein stability and function but also provided a practical, automated framework that other researchers have adopted to accelerate protein structure discovery. His achievements underscore the importance of innovative experimental design in overcoming technical challenges in structural biology.
Research Focus
Key Achievements
Top Papers
- 1