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About

Dr. Ai Kaiho is a leading figure in functional genomics, best known for pioneering advancements in transcriptome analysis. Her primary research focuses on understanding the precise mechanisms of gene transcription initiation and regulation. Dr. Kaiho made a monumental contribution to the field through her work on the FANTOM5 project, where she helped map transcription initiation events across the human and mouse genomes at single base-pair resolution. This landmark study, which has garnered over 360 citations, utilized Cap Analysis of Gene Expression (CAGE) coupled with single-molecule sequencing to monitor transcription frequencies across thousands of samples. To enable this large-scale analysis, Dr. Kaiho developed an automated workflow for preparing cDNA for CAGE on a single-molecule sequencer, a methodological innovation that significantly simplified and accelerated the process. Her technical ingenuity and contributions to high-throughput genomics have provided an invaluable resource for the scientific community, offering a foundational map of gene promoters and enhancers that continues to drive research in gene regulation and disease biology.