Sarthak Saha
Papers
2
Total Citations
22
H-Index
2
About
Sarthak Saha is advancing the frontier of structural biology through innovative microfluidic technologies that streamline protein crystallography. His research centers on developing scalable, high-throughput platforms for room-temperature X-ray diffraction analysis, addressing critical bottlenecks in traditional crystal mounting and data collection. Saha’s most cited work introduces a capillary-based microfluidic device fabricated from UV-curable polymers using cleanroom photolithography, enabling primary high-throughput room-temperature crystallographic screening. This approach accelerates small-molecule compound screening while preserving fragile protein crystals, a significant improvement over conventional methods. Building on this foundation, his 2025 study presents an array-type fixed-target device for automated room-temperature protein crystallography, further enhancing scalability and reducing crystal damage during mounting. Together, these contributions have garnered over 20 citations, reflecting their growing impact on the structural biology community. By merging microfabrication techniques with crystallographic workflows, Saha is democratizing access to rapid, room-temperature structural analysis—a critical step for drug discovery and understanding protein function. His work exemplifies how engineering solutions can transform fundamental biological research, offering practical tools for laboratories worldwide.
Research Focus
Key Achievements
Top Papers
- 1
- 2