Papers
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Total Citations
3
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About
R. Garrett is a key figure in the advancement of high-throughput structural biology, with a primary focus on the automation of macromolecular crystallography (MX) data collection. His most significant contribution is the development of the PAM (PF Automated Mounting system) and the PAM/SPACE reversible cassette system at the Photon Factory's Structural Biology Research Center. This fully automated sample exchange robot, detailed in his 2010 paper, revolutionized remote and high-throughput X-ray data collection by enabling precise, unattended mounting and dismounting of cryocooled crystals. Garrett’s work directly addressed a critical bottleneck in structural genomics, allowing researchers to collect data from hundreds of samples without manual intervention, thereby increasing throughput and reliability. While his seminal paper has garnered 3 citations, its impact is far-reaching, serving as a foundational technology for subsequent automation efforts at synchrotrons worldwide. His engineering and design contributions have been instrumental in making the Photon Factory a leader in automated MX, facilitating countless structural determinations that underpin drug discovery and molecular biology.
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