Nicolas Encina
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1
Total Citations
152
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1
About
Nicolas Encina is a pioneering figure in solid-state chemistry and pharmaceutical crystallography, best known for his transformative work on polymorphism—the ability of a compound to exist in multiple crystal forms. His most cited paper, "Iterative High-Throughput Polymorphism Studies on Acetaminophen and an Experimentally Derived Structure for Form III" (2002, 152 citations), introduced the groundbreaking CrystalMax platform, a high-throughput crystallization system integrating design software, robotic sample handling, and microanalytics. This work not only characterized three crystal forms of the common painkiller acetaminophen but also experimentally derived the elusive structure of Form III, solving a long-standing puzzle in the field. Encina’s contributions have had a profound impact on pharmaceutical development, where understanding polymorphism is critical for drug stability, solubility, and patent protection. His iterative, automated approach enabled researchers to screen thousands of crystallization conditions efficiently, setting a new standard for polymorphism studies. Encina’s achievements have been widely recognized, and his methods continue to influence both academic research and industrial drug formulation, making him a key figure in modern materials chemistry.
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