Andrew M. Goldsweig
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1
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152
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About
Andrew M. Goldsweig is a pioneering researcher in pharmaceutical materials science, with a primary focus on solid-state chemistry and crystal engineering. His most notable contribution is the development of CrystalMax, a high-throughput crystallization platform that revolutionized polymorphism studies. This system integrates design software, robotic sample handling, and microanalytics to rapidly screen thousands of crystallization conditions. Goldsweig's landmark work, "Iterative High-Throughput Polymorphism Studies on Acetaminophen and an Experimentally Derived Structure for Form III" (2002, 152 citations), demonstrated the platform's power by discovering and characterizing three crystal forms of acetaminophen, including the elusive Form III. This achievement provided critical insights into drug stability and bioavailability, influencing pharmaceutical development practices. By enabling systematic exploration of crystal forms, Goldsweig's research has had lasting impact on drug formulation and intellectual property strategies. His work exemplifies how automation and high-throughput methods can accelerate discovery in solid-state chemistry, making him a key figure in modern pharmaceutical materials research.
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