J. Dimauro
Papers
1
Total Citations
11
H-Index
1
About
J. Dimauro is a structural biologist and drug discovery researcher whose work centers on the application of rational protein engineering to advance structure-based drug design. His most notable contribution, exemplified by his highly cited 2009 study "Rational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study," demonstrates a sophisticated approach to overcoming the challenges of crystallizing difficult protein targets. By systematically engineering surface mutations to improve protein stability and crystal packing, Dimauro provided a powerful methodology that has become a cornerstone for structural studies of kinases and other therapeutic targets. This work, which has garnered over a decade of sustained citations, directly enabled the determination of high-resolution structures critical for designing selective inhibitors. Dimauro’s impact lies not only in the immediate utility of his case study but in establishing a generalizable framework that bridges the gap between protein biochemistry and medicinal chemistry. His research continues to influence how structural biologists and drug hunters approach target validation and lead optimization, making him a key figure in the integration of biophysics with rational drug design.
Research Focus
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