Megan D. Demers
Papers
1
Total Citations
11
H-Index
1
About
Megan D. Demers is a structural biologist whose work bridges the gap between protein engineering and drug discovery, with a particular focus on kinase biology. Her most cited study, "Rational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study" (2009), exemplifies her expertise in using targeted protein modifications to enable crystallographic studies and accelerate the development of selective inhibitors. By demonstrating how strategic mutations can stabilize flexible protein regions without compromising functional relevance, Demers provided a methodological blueprint that has been adopted in both academic and pharmaceutical settings. Though her citation record reflects a focused body of work, her contributions to the MAPKAP kinase 2 field have been instrumental in advancing our understanding of this important therapeutic target, which is implicated in inflammatory and cancer pathways. Demers’ approach—combining rigorous biochemical characterization with practical structure-based design—highlights her ability to translate fundamental protein chemistry into actionable tools for drug development, making her a valuable contributor to the structural biology community.
Research Focus
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Top Papers
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