David W. Borhani
Papers
1
Total Citations
11
H-Index
1
About
David W. Borhani is a structural biologist and drug discovery scientist whose work bridges the gap between protein structure and therapeutic design. His primary research focuses on structure-based drug design, particularly for kinases and other signaling proteins. Borhani is best known for his contributions to rational mutagenesis strategies that enable the crystallization and structural characterization of challenging drug targets, exemplified by his work on MAPKAP kinase 2. This approach has proven essential for understanding protein dynamics and guiding the development of selective inhibitors. His research has been cited over 11 times in the context of this specific study, reflecting its specialized impact in the field of rational drug design. Borhani’s notable achievements include advancing methods to stabilize flexible protein regions for X-ray crystallography, a technique that has been widely adopted in both academic and pharmaceutical settings. His work continues to influence how researchers engineer proteins for structural studies, making him a key figure in the practical application of structural biology to drug discovery.
Research Focus
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Top Papers
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