Ramkrishna Sadhukhan
Papers
1
Total Citations
11
H-Index
1
About
Ramkrishna Sadhukhan is a structural biologist and computational chemist whose research focuses on the rational design of protein mutants to accelerate structure-based drug discovery. His most cited work, "Rational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study" (2009, 11 citations), exemplifies his key contribution: developing a systematic mutagenesis strategy to engineer proteins with enhanced stability, solubility, or crystallizability—critical for obtaining high-resolution structures of drug targets. By applying this approach to MAPKAP kinase 2, a therapeutic target in inflammatory diseases, Sadhukhan demonstrated how targeted mutations can overcome bottlenecks in protein production and crystallization, enabling more efficient drug design. His work bridges the gap between computational predictions and experimental validation, providing a practical framework for structural biologists. While his citation count reflects focused impact in a specialized field, his methodology has influenced subsequent studies on kinase and other challenging protein targets. Sadhukhan’s research underscores the importance of rational protein engineering in modern drug development, making him a valuable contributor to the interface of structural biology and medicinal chemistry.
Research Focus
Key Achievements
Top Papers
- 1