Baofu Ni
Papers
1
Total Citations
11
H-Index
1
About
Baofu Ni is a structural biologist and drug discovery researcher whose work bridges the gap between protein engineering and rational drug design. His primary research focuses on kinase biology, structure-based drug design, and the application of mutagenesis to stabilize proteins for therapeutic targeting. Ni’s most notable contribution is his 2009 study on MAPKAP kinase 2, where he demonstrated how rational mutagenesis can be used to support structure-based drug design—a critical approach for developing selective inhibitors against challenging kinase targets. This work has garnered 11 citations, reflecting its influence in the field of targeted cancer therapy and inflammatory disease research. By systematically engineering protein stability and conformational states, Ni’s methodology enables more accurate crystallographic studies and high-throughput screening, accelerating the discovery of lead compounds. His research exemplifies how integrating molecular biology with computational and structural techniques can overcome bottlenecks in drug development. For students and researchers, Ni’s work offers a practical blueprint for using mutagenesis to unlock the structural secrets of difficult proteins, making him a valuable contributor to the ongoing evolution of rational drug design.
Research Focus
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Top Papers
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