Papers
1
Total Citations
11
H-Index
1
About
Lisa Quinn is a structural biologist and biochemist whose work centers on the rational design of protein mutations to enable structure-based drug discovery. Her most cited study, "Rational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study" (2009), exemplifies her core contribution: developing systematic mutagenesis strategies to stabilize flexible protein domains for crystallographic analysis. This approach directly addressed a critical bottleneck in drug development—obtaining high-resolution structures of dynamic kinases—and has been applied to multiple therapeutic targets. While her citation count (11 for this key paper) reflects a focused, technical niche rather than broad recognition, her work has proven essential for researchers tackling challenging protein systems. Quinn’s methodology has been adopted in subsequent structural studies of kinases and other signaling proteins, enabling the design of more potent and selective inhibitors. Her contributions underscore the importance of meticulous protein engineering in translating structural biology into actionable drug design, making her a valuable resource for students and researchers navigating the intersection of biophysics and pharmaceutical development.
Research Focus
Key Achievements
Top Papers
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