Isabelle Sorel
Papers
1
Total Citations
15
H-Index
1
About
Isabelle Sorel is a structural biologist whose work has centered on overcoming the crystallization bottlenecks that have historically hindered high-throughput X-ray crystallography. As a key contributor to the South Paris Yeast Structural Genomics Project, Sorel pioneered automated, nanodrop-based crystal screening strategies that demonstrated how standardized, high-throughput protocols could be applied broadly—challenging the prevailing notion that crystallization conditions must be painstakingly optimized for each individual protein. Her most cited work (15 citations) established a foundational framework for robotic crystallization, showing that a "one size fits all" approach could dramatically accelerate structural determination. While her citation count reflects the specialized, methodological nature of her contributions, Sorel’s impact is felt in every structural genomics pipeline that now relies on automated nanodrop technology. By helping to move the bottleneck from crystallization to downstream analysis, she enabled the high-speed protein structure determination that underpins modern drug discovery and molecular biology. Her work remains a cornerstone reference for researchers seeking to streamline structural genomics workflows.
Research Focus
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Top Papers
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