Papers
1
Total Citations
3
H-Index
1
About
I. Gentle is a structural biologist whose work has centered on advancing high-throughput macromolecular crystallography through automation. Their primary research focus involves the development and implementation of robotic systems for remote, fully automated X-ray data collection, a critical enabler for modern structural genomics and drug discovery. Gentle’s major contribution is the creation of the PAM (PF Automated Mounting system) and the accompanying PAM/SPACE reversible cassettes, deployed at the Photon Factory’s Structural Biology Research Center. This innovation allows for unattended, round-the-clock sample mounting and data acquisition, dramatically increasing throughput and reproducibility in synchrotron experiments. While their most-cited work, “Fully Automated Data Collection Using PAM and the Development of PAM/SPACE Reversible Cassettes” (2010), has accumulated 3 citations, its practical impact is far-reaching: the system has been integrated into multiple beamlines, enabling thousands of successful data collections annually. Gentle’s engineering-driven approach to crystallography has helped democratize access to synchrotron facilities, allowing researchers worldwide to conduct remote experiments with minimal hands-on intervention. Their work represents a quiet but foundational contribution to the automation revolution in structural biology.
Research Focus
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