Charlie Chandsawangbhuwana

La Jolla Bioengineering Institute, University of California San Diego

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About

Charlie Chandsawangbhuwana is a pioneering researcher in the field of biophysics and reproductive biology, with a primary focus on sperm motility and energetics. His work bridges engineering and biology, developing innovative tools to analyze the fundamental mechanics of sperm cells. His most notable contributions include the creation of an automatic system to study sperm motility and energetics (2008, 29 citations), which introduced a novel approach to quantifying sperm swimming behavior. In a landmark study (2008, 24 citations), Chandsawangbhuwana combined laser tweezers with custom computer tracking software and robotics to simultaneously measure sperm motility—including swimming speed, curvilinear velocity (VCL), and swimming force (escape laser power, Pesc)—alongside mitochondrial membrane potential (MP), a key indicator of cellular energetics. This work, conducted using domestic dog sperm, provided unprecedented insight into the relationship between sperm energy production and movement. By integrating optical trapping with automated analysis, Chandsawangbhuwana has advanced our understanding of sperm function at the single-cell level, offering valuable tools for fertility research and reproductive medicine.