Papers
6
Total Citations
74
H-Index
4
About
Linda Shi is a pioneer in the application of optical trapping and laser microsurgery to cell biology, with a particular focus on reproductive physiology and subcellular manipulation. Her research centers on developing automated, robotic laser systems—such as the "RoboLase"—that combine laser tweezers, scissors, and custom computer tracking to study the biomechanics and energetics of individual cells. Shi’s most influential work involves using these tools to analyze sperm motility and mitochondrial function, where she quantified swimming speed, curvilinear velocity, and swimming force in domestic dog sperm, integrating laser tweezers with robotics for high-precision, single-cell analysis. Her 2008 paper on an automatic system for studying sperm motility and energetics has garnered 29 citations, while her 2008 study on laser tweezers and mitochondrial membrane potential has 24 citations, underscoring her impact in reproductive biophysics. Shi has also advanced optical micromanipulation of chromosomes inside living cells, developing a dual-joystick-controlled system for trapping and cutting organelles. Her interdisciplinary approach bridges engineering, physics, and biology, offering powerful tools for studying cell physiology and evolution.
Research Focus
Key Achievements
Top Papers
- 1An automatic system to study sperm motility and energetics29 citations · 2008
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- 6"RoboLase": A robotic laser scissors and laser tweezers microscope2 citations · 2006