Zhong Zhong

Institute of Medical Cell Technologies, Phillips University

Papers

Total Citations

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About

Zhong Zhong is a specialist in cell-based assay development and high-throughput screening (HTS) technologies, with a particular focus on solving one of the field's most persistent technical challenges: ensuring consistent, reliable cellular reagents for large-scale drug discovery operations. His most influential contributions center on the development and application of division arrest technology, a methodology that uses low-level mitomycin C treatment to halt cell proliferation while preserving functional cellular responses. This innovation addressed a critical bottleneck in HTS workflows — the difficulty of maintaining uniform cell populations across multi-day or multi-week screening campaigns. Zhong's research demonstrated that division-arrested cells outperform or match both fresh and frozen cell preparations in terms of consistency and assay robustness, findings published across three complementary studies in 2005 that collectively garnered 60 citations. His work extended into high-content screening platforms, broadening the practical applicability of his approach across diverse detection technologies. By reframing cells as precision-engineered reagents rather than biological variables, Zhong made a meaningful contribution to the reproducibility and scalability of pharmaceutical screening pipelines — work that remains relevant to researchers designing cell-based assays in academic and industrial settings today.