Mark Federici

Papers

Total Citations

H-Index

About

Mark Federici is a researcher specializing in cell-based assay development and high-throughput screening (HTS) methodologies, with a particular focus on improving the reliability and consistency of cellular reagents used in drug discovery pipelines. His most notable contributions center on the innovative application of division-arrested cells to enhance assay performance in both standard and high-content screening platforms. In his 2005 publications, Federici demonstrated that treating cells with low-level mitomycin C to arrest cell division could dramatically improve the consistency and quality of cellular reagents — a critical challenge in robotic high-throughput screening environments. By addressing one of the most variable and unpredictable components of cell-based assays, his work helped lay practical groundwork for more reproducible compound screening workflows. These contributions have collectively garnered 27 citations, reflecting their meaningful utility to researchers working at the intersection of cell biology and pharmaceutical screening. Federici's work speaks to the often-overlooked but essential operational challenges in drug discovery: ensuring that the biological tools themselves are standardized and reliable. His research remains a valuable reference for scientists designing robust HTS and high-content imaging assays in academic and industrial settings alike.