Thomas J. Livelli
Papers
2
Total Citations
27
H-Index
2
About
Thomas J. Livelli’s research centers on the critical challenge of assay reproducibility in high-throughput and high-content screening, with a particular focus on the biological variability introduced by live cells. His major contribution lies in pioneering the use of division-arrested cells as a standardized, consistent reagent for robotic compound screening. By demonstrating that cells treated with low-level mitomycin C could maintain functionality while halting division, Livelli provided a practical solution to a fundamental bottleneck in drug discovery: the inherent inconsistency of proliferating cell populations. His two most-cited papers, both from 2005, have collectively garnered 27 citations, establishing a foundational methodology that has influenced assay design in both academic and industrial settings. This work is notable for its direct impact on the robustness of cell-based assays, transforming cells from a variable component into a reliable reagent. Livelli’s research remains a key reference for scientists seeking to improve the quality and reproducibility of their screening data, underscoring his lasting contribution to the field of assay development.
Research Focus
Key Achievements
Top Papers
- 1Improving Consistency of Cell-Based Assays by Using Division-Arrested Cells17 citations · 2005
- 2