Zhen Han Liu
Papers
1
Total Citations
58
H-Index
1
About
Zhen Han Liu is a pioneering researcher in cellular signaling and high-throughput drug discovery, with a primary focus on intracellular calcium dynamics and G-protein coupled receptor (GPCR) pharmacology. Their seminal 2003 work, "Measuring Intracellular Calcium Fluxes in High Throughput Mode," has garnered 58 citations and fundamentally advanced real-time calcium flux measurement techniques. This innovation enabled pharmaceutical researchers to efficiently characterize GPCR activation and screen for novel ligands, initially targeting Gq-coupled receptors. Liu’s contributions have streamlined the transition from basic cellular signaling studies to industrial-scale drug screening, accelerating the identification of therapeutic candidates. By developing robust high-throughput methodologies, they bridged the gap between academic calcium imaging and commercial drug development, impacting fields from neuropharmacology to metabolic disease research. Their work remains a cornerstone for researchers seeking to decode receptor-ligand interactions, demonstrating how precise measurement of intracellular signals can transform both fundamental biology and applied pharmaceutical science.
Research Focus
Key Achievements
Top Papers
- 1Measuring Intracellular Calcium Fluxes in High Throughput Mode58 citations · 2003