Paul M. Hayter
Papers
1
Total Citations
58
H-Index
1
About
Paul M. Hayter is a leading figure in the development of high-throughput cellular assays, with a primary focus on intracellular calcium flux measurement and G-protein coupled receptor (GPCR) pharmacology. His seminal 2003 work, "Measuring Intracellular Calcium Fluxes in High Throughput Mode" (58 citations), established a foundational methodology for real-time calcium monitoring, enabling the pharmaceutical industry to rapidly characterize GPCR activation and screen for novel surrogate ligands. This contribution revolutionized early-stage drug discovery by moving beyond the initial restriction to G(q)-coupled receptors, broadening the scope of high-throughput screening. Hayter’s research has had a lasting impact on assay miniaturization and kinetic analysis, providing tools that accelerate the identification of therapeutic candidates. His work is widely cited by researchers in cell signaling and drug development, reflecting its enduring relevance. Through these innovations, Hayter has helped bridge the gap between basic cellular physiology and industrial-scale pharmacology, making him a key contributor to modern assay technologies.
Research Focus
Key Achievements
Top Papers
- 1Measuring Intracellular Calcium Fluxes in High Throughput Mode58 citations · 2003