Andreas Sewing

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About

Andreas Sewing is a distinguished researcher whose work has significantly advanced the field of cellular pharmacology, with a particular focus on G-protein coupled receptor (GPCR) biology and high-throughput screening technologies. His research has fundamentally shaped how the pharmaceutical industry approaches drug discovery, particularly in developing and refining cell-based assays that provide critical functional data on compound activity. Sewing’s most impactful contribution is his pioneering work on measuring intracellular calcium fluxes in high-throughput mode (2003, 58 citations). This research revolutionized the pharmaceutical industry's ability to study GPCR activation in real time, enabling both pharmacological characterization and large-scale screening for new surrogate ligands. His work addressed the critical challenge of efficiently detecting Gq-coupled receptor activation, a cornerstone of modern drug discovery. Further expanding on this theme, his 2005 paper (19 citations) provided a crucial framework for understanding the balance between measuring affinity versus efficacy in GPCR assays, arguing that functional cell-based assays must complement traditional biochemical screens to provide a complete picture of compound effects. Through these contributions, Sewing has helped bridge the gap between high-throughput screening and meaningful pharmacological data, leaving a lasting impact on how researchers design and interpret drug discovery programs.