Sandra Marcos

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About

Sandra Marcos is a leading figure in cellular signaling and high-throughput drug discovery, with her work fundamentally shaping how the pharmaceutical industry screens for new therapeutics. Her primary research focuses on the real-time measurement of intracellular calcium fluxes, a critical technique for studying G-protein coupled receptors (GPCRs). Her most influential work, the 2003 paper "Measuring Intracellular Calcium Fluxes in High Throughput Mode," has garnered 58 citations and remains a cornerstone reference for researchers. This paper established the methodological framework for using calcium flux assays to pharmacologically characterize GPCRs and screen for surrogate ligands, a process initially restricted to Gq-coupled receptors. By enabling high-throughput, real-time analysis of these signaling pathways, Marcos provided the tools necessary for rapid drug target validation and lead compound identification. Her contributions have directly accelerated the pace of preclinical drug development, making her a pivotal figure in bridging fundamental cell biology with applied pharmaceutical research.