Philip Gribbon
Papers
1
Total Citations
58
H-Index
1
About
Philip Gribbon is a leading figure in the development of high-throughput screening (HTS) technologies, with a particular focus on assay miniaturization and the measurement of intracellular signaling. His seminal 2003 work on measuring intracellular calcium fluxes in high throughput mode (58 citations) established a foundational method for the pharmaceutical industry, enabling the real-time pharmacological characterization of G-protein coupled receptors (GPCRs) and the screening of surrogate ligands. This contribution, initially focused on G(q)-coupled pathways, helped democratize functional cell-based assays for drug discovery. Gribbon's broader research centers on advancing HTS platforms, integrating label-free detection, and developing robust phenotypic screening strategies to bridge the gap between target-based and cell-based approaches. His work has been instrumental in improving assay reproducibility and throughput, directly impacting how large chemical libraries are interrogated for novel therapeutics. By refining the tools for measuring dynamic cellular processes, Gribbon has enabled researchers to more efficiently identify lead compounds, making him a key architect of modern, high-information-content screening paradigms.
Research Focus
Key Achievements
Top Papers
- 1Measuring Intracellular Calcium Fluxes in High Throughput Mode58 citations · 2003