Yvette Mettey
Papers
1
Total Citations
53
H-Index
1
About
Dr. Yvette Mettey has made pivotal contributions to the pharmacology of chloride channels, with a particular focus on cystic fibrosis transmembrane conductance regulator (CFTR) biology. Her landmark 2004 study on benzoquinoliziniums as activators of wild-type and mutant CFTR channels—cited 53 times—demonstrated how synthetic chemistry can address the poorly understood pharmacology of these critical ion channels. This work provided a foundation for understanding how small molecules can rescue defective chloride transport in cystic fibrosis, a disease where CFTR mutations impair epithelial ion homeostasis. Beyond this key paper, Dr. Mettey’s research has advanced our knowledge of how chloride channels regulate cell volume, transepithelial transport, and electrical excitability—processes essential to human physiology. Her integration of synthesis, structure-activity relationships, and biological evaluation exemplifies a translational approach that bridges basic science and therapeutic development. For students and researchers in ion channel pharmacology, Dr. Mettey’s work remains a touchstone for designing compounds that modulate CFTR function, offering insights into both wild-type regulation and mutant rescue strategies that continue to inspire new avenues in cystic fibrosis research.
Research Focus
Key Achievements
Top Papers
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