Papers
3
Total Citations
172
H-Index
3
About
Caroline Norez is a biomedical researcher whose work centers on ion channel biology, with a particular focus on the cystic fibrosis transmembrane conductance regulator (CFTR) and its role in human disease. Her research spans two interconnected domains: the molecular pharmacology of chloride channels and the genetic basis of reproductive disorders linked to CFTR dysfunction. Norez's most impactful contribution, cited 116 times, identified missense mutations in SLC26A8—a sperm-specific activator of CFTR—as a cause of human asthenozoospermia, a condition characterized by impaired sperm motility and a significant driver of male infertility. This discovery forged an important link between CFTR signaling and reproductive biology. Her earlier work, garnering 53 citations, investigated benzoquinolizinium compounds as pharmacological activators of both wild-type and mutant CFTR channels, advancing understanding of chloride channel pharmacology at a time when therapeutic options for cystic fibrosis remained limited. She has also contributed to cataloguing orphan missense mutations in CFTR, helping to characterize variants of uncertain clinical significance. Through her research, Norez has meaningfully advanced our understanding of CFTR-related pathologies beyond the lung, opening avenues for therapeutic development in both cystic fibrosis and male infertility.
Research Focus
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