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Total Citations
116
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About
Dr. M. Jollivet is a leading figure in reproductive genetics, whose work has fundamentally advanced our understanding of the molecular mechanisms underlying male infertility. Her research focuses on the genetic basis of sperm function, particularly the roles of ion channels and transporters in sperm motility and maturation. Her most impactful contribution is the landmark 2013 study identifying missense mutations in the *SLC26A8* gene as a cause of human asthenozoospermia, a condition characterized by severely reduced sperm motility. This work, which has garnered over 116 citations, was the first to demonstrate that SLC26A8 acts as a sperm-specific activator of the CFTR chloride channel, revealing a critical signaling pathway for flagellar movement. By linking a specific genetic defect to a common form of male infertility, Jollivet’s research provides a clear diagnostic target and opens new avenues for therapeutic intervention. Her findings are not only a cornerstone for clinical genetic testing but also a powerful example of how basic cell biology can directly address a pressing human health challenge.
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