J.‐M. VIERFOND
Papers
1
Total Citations
53
H-Index
1
About
J.-M. Vierfond is a leading medicinal chemist whose work has profoundly advanced the pharmacology of chloride channels, particularly in the context of cystic fibrosis (CF). His research focuses on the design, synthesis, and structure-activity relationships (SAR) of small molecules that modulate ion transport, with a key contribution being the development of benzoquinolizinium compounds as activators of the cystic fibrosis transmembrane conductance regulator (CFTR) channel. His seminal 2004 paper, which has garnered 53 citations, laid critical groundwork by combining synthesis, SAR, and crystal structure analysis to target both wild-type and mutant CFTR—a breakthrough for addressing the underlying defect in CF. Vierfond’s work bridges organic chemistry and cellular physiology, providing tools to correct chloride transport dysfunction. His achievements are notable for their translational potential, offering a path toward novel therapeutics for CF and other channelopathies. By illuminating the poorly understood pharmacology of chloride channels, Vierfond has established himself as a key figure in ion channel drug discovery, inspiring further research into targeted modulators of epithelial transport.
Research Focus
Key Achievements
Top Papers
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