Laurence Bulteau‐Pignoux
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1
Total Citations
53
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1
About
Laurence Bulteau‐Pignoux is a leading researcher in medicinal chemistry and ion channel pharmacology, with a primary focus on cystic fibrosis (CF) transmembrane conductance regulator (CFTR) modulators. Her seminal 2004 work on benzoquinoliziniums as CFTR activators (53 citations) represents a foundational contribution to the field, demonstrating how small molecules can rescue both wild-type and mutant CFTR channels—a critical insight for developing therapies targeting the underlying defect in cystic fibrosis. This research bridged synthetic chemistry, structure-activity relationships, and crystallography to elucidate mechanisms of chloride channel modulation, addressing a historically underdeveloped area of pharmacology. Her work has directly informed subsequent efforts to correct CFTR dysfunction, impacting the design of potentiators and correctors now used in clinical settings. By advancing the pharmacology of chloride channels beyond genetic characterization, Bulteau‐Pignoux has helped pave the way for precision therapies that restore ion transport in CF patients, making her contributions essential reading for anyone studying CFTR biology or ion channel drug discovery.
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