Dung Nguyen‐Huy
Papers
1
Total Citations
53
H-Index
1
About
Dr. Dung Nguyen-Huy is a distinguished medicinal chemist whose work has significantly advanced the understanding and pharmacological targeting of chloride channels, particularly in the context of cystic fibrosis (CF). Her research focuses on the design, synthesis, and structure-activity relationships (SAR) of small molecules that modulate ion transport, with a key contribution being the development of benzoquinolizinium compounds as activators of the cystic fibrosis transmembrane conductance regulator (CFTR) channel. Her most-cited paper, "Synthesis, SAR, Crystal Structure, and Biological Evaluation of Benzoquinoliziniums as Activators of Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Channels" (2004, 53 citations), exemplifies this work by providing a comprehensive chemical and biological characterization of these novel activators, offering a foundation for potential therapeutics targeting both wild-type and mutant CFTR. This research addresses a critical gap in chloride channel pharmacology, which remains poorly understood despite its importance in homeostasis, cell volume regulation, and transepithelial transport. Dr. Nguyen-Huy’s contributions have not only enriched the chemical biology of ion channels but also paved the way for future drug discovery efforts in CF and related disorders.
Research Focus
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Top Papers
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