Wen-Xuan Zhao

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About

Wen-Xuan Zhao is a pioneering researcher in the field of nanobiotechnology, with a primary focus on engineering biomolecular machines that harness energy from electrochemical gradients. His most notable contribution is the design and experimental demonstration of a DNA turbine powered by a transmembrane potential across a nanopore—a landmark achievement published in 2023. This work, which has already garnered 51 citations, represents the first functional synthetic nanoscale turbine capable of transducing ionic gradients into mechanical rotation, directly mimicking the core mechanism of ATP synthase. By integrating DNA origami with solid-state nanopores, Zhao has opened a new paradigm for constructing artificial rotary motors that operate at the molecular scale. His research bridges fundamental biophysics and applied nanotechnology, offering a platform for future developments in nanofluidics, energy conversion, and synthetic biology. Zhao’s work stands out for its elegant combination of structural DNA nanotechnology and single-molecule electrophysiology, demonstrating both technical ingenuity and profound insight into biological energy transduction.