Sahir Khurshid

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About

Sahir Khurshid is a structural biologist whose work bridges fundamental biophysics and practical crystallographic methods. His research centers on the molecular mechanisms of cardiac muscle function, with a particular focus on the cardiac isoform of myosin-binding protein C (cMyBP-C). In his highly cited 2008 study, Khurshid investigated the protonation states of the C1 domain of cMyBP-C, a protein critical for cardiac contraction and subject to reversible phosphorylation. By elucidating how surface-charge states influence inter-protein interactions, his work provided foundational insights into the regulatory role of cMyBP-C in heart muscle physiology, contributing to our understanding of cardiac disease mechanisms. Beyond this biological focus, Khurshid made a significant technical contribution to structural biology with his 2010 paper on automated seeding for crystal optimization. Recognizing that manual seeding remained a bottleneck in high-throughput structural genomics, he devised a method to automate this process, dramatically improving crystal quality and reproducibility. This innovation has streamlined protein structure determination pipelines, enabling more efficient drug discovery and structural studies. With over 30 combined citations, Khurshid’s work demonstrates impact both in advancing cardiac molecular biology and in developing practical tools that empower the broader crystallographic community.