Stuart Fisher
Papers
1
Total Citations
20
H-Index
1
About
Stuart Fisher’s research centers on the molecular biophysics of cardiac muscle, with a particular focus on the structure and function of cardiac myosin-binding protein C (cMyBP-C). His major contribution lies in elucidating the protonation states of the C1 domain of cMyBP-C, a critical region that governs inter-protein interactions within the sarcomere. By investigating how reversible phosphorylation alters the surface-charge state of this domain, Fisher has provided foundational insights into the electrostatic mechanisms that regulate cardiac contractility. His most cited work, “An investigation into the protonation states of the C1 domain of cardiac myosin-binding protein C” (2008), has garnered 20 citations, reflecting its importance in the field of muscle biophysics. This study is notable for bridging computational chemistry and experimental structural biology, offering a detailed electrostatic map of a domain central to heart function. Fisher’s work is particularly relevant for researchers studying hypertrophic cardiomyopathy, as mutations in cMyBP-C are a leading cause of the disease. His careful analysis of charge dynamics continues to inform therapeutic strategies targeting myofilament regulation.
Research Focus
Key Achievements
Top Papers
- 1