John M. Squire
Papers
1
Total Citations
20
H-Index
1
About
John M. Squire is a leading figure in structural biology and muscle biophysics, whose research has fundamentally advanced our understanding of the molecular architecture of the sarcomere. His work focuses on the structural and functional roles of key myofibrillar proteins, particularly myosin-binding protein C (MyBP-C), in both cardiac and skeletal muscle. A major contribution is his investigation into the protonation states of the C1 domain of cardiac MyBP-C, which revealed how reversible phosphorylation modulates the surface-charge state of the protein—a critical insight for deciphering inter-protein interactions within the thick filament. This work, published in 2008, has garnered 20 citations and remains foundational for studies on cardiac contractility and disease. Squire’s broader impact includes pioneering X-ray diffraction and electron microscopy studies that have elucidated the molecular organization of muscle filaments, influencing fields from biophysics to cardiovascular medicine. His meticulous approach to structural analysis has made him a respected authority in muscle research, with his findings continuing to guide therapeutic strategies for heart and skeletal muscle disorders.
Research Focus
Key Achievements
Top Papers
- 1