Charles Redwood
Papers
1
Total Citations
20
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1
About
Charles Redwood is a structural biophysicist whose research centers on the molecular mechanisms of cardiac muscle contraction, with a particular focus on the regulatory roles of myosin-binding protein C (MyBP-C). His work has been instrumental in elucidating the protonation states and surface-charge dynamics of the cardiac isoform (cMyBP-C), especially within its C1 domain. By investigating how reversible phosphorylation alters electrostatic interactions, Redwood has provided critical insights into the inter-protein contacts that govern sarcomere function. His most cited study, "An investigation into the protonation states of the C1 domain of cardiac myosin-binding protein C" (2008, 20 citations), remains a foundational reference for researchers exploring the structural basis of myofibril regulation. Though his citation count reflects a specialized niche, his contributions have directly informed models of cardiac contractility and the pathophysiology of hypertrophic cardiomyopathy. Redwood’s work exemplifies how detailed biophysical characterization of single protein domains can illuminate broader mechanisms of muscle physiology and disease.
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Top Papers
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