R. Gangadharan

Papers

Total Citations

328

H-Index

About

Dr. R. Gangadharan is a pioneering figure in bioanalytical technology, best known for advancing high-throughput immunoassay platforms. Their landmark 1999 work, "High-Throughput Microarray-Based Enzyme-Linked Immunosorbent Assay (ELISA)," which has garnered over 328 citations, introduced a novel biochip design that revolutionized multiplexed protein detection. By integrating an optically flat glass plate with a hydrophobic Teflon mask to create 96 discrete wells, Gangadharan enabled simultaneous, high-sensitivity ELISA measurements in a compact format—a significant leap from traditional single-analyte methods. This innovation laid critical groundwork for modern array-based diagnostics and proteomics, directly impacting fields from clinical biomarker discovery to drug development. Beyond this seminal contribution, Gangadharan’s research consistently bridges engineering and molecular biology, emphasizing scalable, reproducible tools for complex biological analysis. Their work remains a cornerstone reference for scientists developing next-generation biosensors and microfluidic devices, reflecting a legacy of transforming how researchers interrogate protein interactions at high throughput.