Papers
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Total Citations
543
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About
Nathan Mudie is a leading figure in synchrotron science, whose work has profoundly shaped modern crystallography infrastructure. His primary research areas encompass X-ray beamline design, macromolecular crystallography, and the development of advanced instrumentation for structural biology. Mudie’s major contribution is the conception and realization of the MX2 beamline at the Australian Synchrotron, a high-flux, in-vacuum undulator microfocus facility that serves both the chemical and macromolecular crystallography communities. This beamline, delivering hard X-rays (4.8–21 keV) with a flux of 3.4 × 10¹² photons s⁻¹ at 13 keV and a focal spot of just 22 × 12 µm, has become an indispensable tool for researchers worldwide. Its impact is reflected in over 540 citations for the foundational 2018 paper describing its design and performance. By enabling high-resolution data collection from tiny or weakly diffracting crystals, Mudie’s work has accelerated discoveries in drug design, enzymology, and materials science. His achievement stands as a benchmark for next-generation synchrotron beamlines, demonstrating how careful engineering can bridge the gap between chemical and biological crystallography.
Research Focus
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