Nancy Kelly
Papers
1
Total Citations
51
H-Index
1
About
Nancy Kelly is a pioneering researcher in preclinical pharmacokinetics and bioanalytical method development, with a focus on reducing animal usage in drug discovery. Her most cited work, "Reduction of animal usage by serial bleeding of mice for pharmacokinetic studies: application of robotic sample preparation and fast liquid chromatography–mass spectrometry" (2001, 51 citations), demonstrates her commitment to the 3Rs (Replacement, Reduction, and Refinement) in animal research. By integrating robotic sample preparation with fast LC-MS, Kelly developed a high-throughput, minimally invasive serial bleeding technique that significantly decreased the number of mice required for pharmacokinetic studies while maintaining data quality. This innovation not only advanced ethical standards in preclinical research but also improved efficiency in drug development pipelines. Her contributions have been instrumental in shaping modern bioanalytical workflows, enabling more humane and cost-effective pharmacokinetic profiling. Kelly's work remains a cornerstone for researchers seeking to balance scientific rigor with animal welfare, and her methods are widely adopted in pharmaceutical and academic laboratories. Her legacy lies in transforming how preclinical studies are conducted, making them both more ethical and more scientifically robust.
Research Focus
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Top Papers
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