Chi-Chung Chan
Papers
1
Total Citations
51
H-Index
1
About
Chi-Chung Chan is a pharmaceutical scientist whose work has advanced preclinical pharmacokinetic studies through innovative methods that reduce animal usage. His most cited paper, “Reduction of animal usage by serial bleeding of mice for pharmacokinetic studies: application of robotic sample preparation and fast liquid chromatography–mass spectrometry” (2001, 51 citations), exemplifies his commitment to the 3Rs (Replacement, Reduction, and Refinement) in animal research. By integrating robotic sample preparation with fast LC-MS, Chan demonstrated how serial bleeding from a single mouse could replace traditional composite profiles from multiple animals, significantly lowering the number of rodents needed for drug absorption, distribution, metabolism, and excretion (ADME) studies. This methodological breakthrough not only improved data quality—since each animal serves as its own control—but also aligned with ethical standards in biomedical research. Chan’s contributions are particularly valuable for students and researchers in pharmacokinetics and drug development, offering a practical, humane, and efficient approach to early-stage compound screening. His work remains a reference point for those seeking to balance scientific rigor with animal welfare in pharmaceutical research.
Research Focus
Key Achievements
Top Papers
- 1