Lijing Xu
Papers
1
Total Citations
51
H-Index
1
About
Dr. Lijing Xu is a pioneering researcher in bioanalytical chemistry and preclinical pharmacokinetics, best known for advancing humane and efficient methodologies in drug development. Her most cited work, "Reduction of animal usage by serial bleeding of mice for pharmacokinetic studies" (2001, 51 citations), exemplifies her commitment to the 3Rs principle—Replacement, Reduction, and Refinement—in animal research. In this landmark study, she integrated robotic sample preparation with fast liquid chromatography–mass spectrometry (LC-MS), enabling serial blood sampling from a single mouse rather than sacrificing multiple animals per time point. This innovation not only drastically reduced animal usage but also improved data quality by minimizing inter-subject variability. Dr. Xu’s contributions have had a lasting impact on pharmaceutical research, providing a template for high-throughput, ethical pharmacokinetic profiling. Her work bridges analytical chemistry and animal welfare, demonstrating that rigorous science and ethical practice can go hand in hand. For students and researchers in drug discovery, Dr. Xu’s approach remains a model of methodological ingenuity and responsible research conduct.
Research Focus
Key Achievements
Top Papers
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