Pharmacokinetics

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

Anna Herland, Ben M. Maoz, Debarun Das, Mahadevabharath R. Somayaji, Rachelle Prantil‐Baun, Richard Novák, Michael J. Cronce, Tessa Huffstater, Sauveur S. F. Jeanty, Angeliki Chalkiadaki, David B. Chou, Susan Marquez, Aaron Delahanty, Sasan Jalili‐Firoozinezhad, Yuka Milton, Alexandra Sontheimer-Phelps, Ben Swenor, Oren Levy, Kevin Kit Parker, Andrzej Przekwas, Donald E. Ingber

Citations: 463 • 2020

Metabolic Stability for Drug Discovery and Development

Collen Masimirembwa, Ulf Bredberg, Tommy B. Andersson

Citations: 219 • 2003

Discovery stage pharmacokinetics using dried blood spots

Patrick Beaudette, Kevin P. Bateman

Citations: 134 • 2004

Rapid stereospecific high-performance liquid chromatographic determination of levofloxacin in human plasma and urine

Frankie A. Wong, Stephen J. Juzwin, S Flor

Citations: 122 • 1997

Pharmacokinetics of vindesine and vincristine in humans.

Richard J. Owellen, Mary A. Root, Frederick O. Hains

Citations: 102 • 1977

Robotically handled whole-tissue culture system for the screening of oral drug formulations

Thomas von Erlach, Sarah H. Saxton, Yunhua Shi, Daniel Minahan, Daniel Reker, Farhad Javid, Young‐Ah Lucy Lee, Carl M. Schoellhammer, Tina Esfandiary, Cody Cleveland, Lucas Booth, Jiaqi Lin, Hannah Levy, Sophie M. Blackburn, Alison Hayward, Róbert Langer, Giovanni Traverso

Citations: 52 • 2020

Reduction of animal usage by serial bleeding of mice for pharmacokinetic studies: application of robotic sample preparation and fast liquid chromatography–mass spectrometry

Kevin P. Bateman, Geneviève Castonguay, Lijing Xu, Steve Rowland, Deborah A. Nicoll‐Griffith, Nancy Kelly, Chi-Chung Chan

Citations: 51 • 2001

Quantification of Apixaban, Dabigatran, Edoxaban, and Rivaroxaban in Human Serum by UHPLC-MS/MS—Method Development, Validation, and Application

Sofia Lindahl, Roar Dyrkorn, Olav Spigset, Solfrid Hegstad

Citations: 50 • 2018

Comparison of the quantification of acetaminophen in plasma, cerebrospinal fluid and dried blood spots using high-performance liquid chromatography–tandem mass spectrometry

Rachel R. Taylor, Keith L. Hoffman, Björn Schniedewind, Claudia Clavijo, Jeffrey L. Galinkin, Uwe Christians

Citations: 50 • 2013

A high-throughput U-HPLC–MS/MS assay for the quantification of mycophenolic acid and its major metabolites mycophenolic acid glucuronide and mycophenolic acid acyl-glucuronide in human plasma and urine

Jacek Klepacki, Jelena Klawitter, Jamie Bendrick‐Peart, Björn Schniedewind, Svenja Heischmann, Touraj Shokati, Uwe Christians, Jost Klawitter

Citations: 49 • 2011

Rapid determination of the anti-cancer drug chlorambucil (Leukeran™) and its phenyl acetic acid mustard metabolite in human serum and plasma by automated solid-phase extraction and liquid chromatography–tandem mass spectrometry

Ieuan Davies, Jane Allanson, Roger C. Causon

Citations: 49 • 1999

Approaches to higher-throughput pharmacokinetics (HTPK) in drug discovery

A. Watt, Denise Morrison, David C. Evans

Citations: 47 • 2000

Optimizing a High-Throughput Solid-Phase Microextraction System to Determine the Plasma Protein Binding of Drugs in Human Plasma

Kanchan Sinha Roy, Emir Nazdrajić, Olga Shimelis, Michaela Ross, Yong Chen, Hugh M. Cramer, Janusz Pawliszyn

Citations: 43 • 2021

Image-Guided Po₂ Probe Measurements Correlated with Parametric Images Derived from ¹⁸F-Fluoromisonidazole Small-Animal PET Data in Rats

Rachel M. Bartlett, Bradley J. Beattie, Manoj Naryanan, Jens-Christoph Georgi, Qing Chen, Gordon Roble, Pat Zanzonico, Mithat Gönen, Joseph A. O’Donoghue, Alexander Fischer, John L. Humm

Citations: 37 • 2012

Liquid chromatography with multi-channel electrochemical detection for the determination of epigallocatechin gallate in rat plasma utilizing an automated blood sampling device

Hong Long, Yongxin Zhu, Meloney Cregor, Feifei Tian, Lou Coury, Candice B. Kissinger, Peter T. Kissinger

Citations: 28 • 2001

Quantification of 21 antihypertensive drugs in serum using UHPLC-MS/MS

Per Ole M. Gundersen, Arne Helland, Olav Spigset, Solfrid Hegstad

Citations: 25 • 2018

Application of a semi-automated 96-well format solid-phase extraction, column-switching, fluorescence detection protocol for the determination of alendronate in human urine samples obtained from a bioequivalence study

Constantinos Apostolou, Yannis Dotsikas, Constantinos Kousoulos, Georgia Tsatsou, Filomila Colocouri, Georgios-Stefanos Soumelas, Yannis L. Loukas

Citations: 24 • 2006

An Automated Method for the Determination of Diclofenac Sodium in Human Plasma

Linda A. Brunner, Richard C. Luders

Citations: 23 • 1991

Implantable magnetically-actuated capsule for on-demand delivery

Ying Zheng, Guizhou Zheng, Yuan Yuan Li, Xia Gong, Zhipeng Chen, Linyu Zhu, Yunsheng Xu, Xi Xie, Shuo Wu, Lelun Jiang

Citations: 22 • 2023

Acetaminophen pharmacokinetics in severely obese adolescents and young adults

Mohammed Hakim, Brian J. Anderson, Hina Walia, Dmitry Tumin, Marc P. Michalsky, Ahsan Syed, Joseph D. Tobias

Citations: 21 • 2018