Papers
2
Total Citations
22
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About
Marc Aprahamian is a leading figure in preclinical image-guided interventions, with a focus on robotic systems for small animal models. His research centers on the development of fully automated, minimally invasive platforms that integrate micro-CT imaging with precision needle insertion, primarily applied to oncology. Aprahamian’s major contributions include pioneering a robotized system for intratumoral drug evaluation in hepatocellular carcinoma (HCC) mouse models, addressing the critical challenge of targeted drug delivery in orthotopic liver cancer. His work has enabled serial, non-invasive tissue sampling, reducing the need for large animal cohorts and accelerating longitudinal studies. Among his most cited works, the 2014 study on the HCC model (14 citations) and the 2007 paper on automated needle insertion for small animal biopsies (8 citations) stand out, demonstrating his impact in advancing translational cancer research. Aprahamian’s innovations bridge engineering and biomedical science, offering reproducible, high-precision tools that enhance preclinical drug evaluation and biological process monitoring.
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