Papers
2
Total Citations
303
H-Index
2
About
Kirk C. Hansen is a leading researcher in proteomics and protein homeostasis, with a focus on understanding the molecular mechanisms underlying human aging and disease. His work bridges cutting-edge mass spectrometry and systems biology to explore how protein dysfunction drives pathology. Hansen’s most-cited paper (295 citations) introduced a groundbreaking protocol using cleavable ¹³C-isotope-coded affinity tags (cICAT) combined with multidimensional chromatography, enabling high-sensitivity, high-coverage identification and quantification of protein mixtures from extremely low-abundance, complex samples—a transformative tool for comparative proteomics. More recently, his 2018 review (8 citations) frames proteins as “nature’s robots” and examines how disruptions in protein homeostasis—the cellular machinery that maintains proper protein folding, trafficking, and degradation—contribute to aging and disease. This work underscores his commitment to translating fundamental proteomic insights into a deeper understanding of age-related pathologies. Hansen’s contributions have advanced both analytical methodology and conceptual frameworks, making him a key figure in the study of proteostasis and its role in human health.
Research Focus
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Top Papers
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